With the important coooling area covered, from a techincal side proglonged use will not have any adverse affect on the system how ever for arguements sake the long the use the better. Why.
1) switching on and off is not good for electrical compontents due to the burst of electricity when switch on, so u could agree turn the system on and off all the time will have a bad effect.
2)If it is a good game play the hell out of it
